Signaling Proteins Are Represented in Tissue Fluid/Lymph from Soft Tissues of Normal Human Legs at Concentrations Different from Serum
Identifieur interne : 003157 ( Main/Exploration ); précédent : 003156; suivant : 003158Signaling Proteins Are Represented in Tissue Fluid/Lymph from Soft Tissues of Normal Human Legs at Concentrations Different from Serum
Auteurs : Marzanna Zaleska ; Waldemar L. Olszewski ; Marek Durlik ; Norman E. MillerSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2013.
Descripteurs français
- KwdFr :
- Cytokines (métabolisme), Humains, Inhibiteur tissulaire de métalloprotéinase-1 (métabolisme), Inhibiteur tissulaire de métalloprotéinase-2 (métabolisme), Jambe (), Lymphe (), Lymphe (métabolisme), Matrix metalloproteinase 9 (métabolisme), Mâle, Protéines et peptides de signalisation intercellulaire (métabolisme), Sérum, Transduction du signal (physiologie), Vaisseaux lymphatiques (), Vaisseaux lymphatiques (métabolisme), Volontaires sains.
- MESH :
- métabolisme : Cytokines, Inhibiteur tissulaire de métalloprotéinase-1, Inhibiteur tissulaire de métalloprotéinase-2, Lymphe, Matrix metalloproteinase 9, Protéines et peptides de signalisation intercellulaire, Vaisseaux lymphatiques.
- physiologie : Transduction du signal.
- Humains, Jambe, Lymphe, Mâle, Sérum, Vaisseaux lymphatiques, Volontaires sains.
English descriptors
- KwdEn :
- Cytokines (metabolism), Healthy Volunteers, Humans, Intercellular Signaling Peptides and Proteins (metabolism), Leg (blood supply), Lymph (chemistry), Lymph (metabolism), Lymphatic Vessels (blood supply), Lymphatic Vessels (metabolism), Male, Matrix Metalloproteinase 9 (metabolism), Serum, Signal Transduction (physiology), Tissue Inhibitor of Metalloproteinase-1 (metabolism), Tissue Inhibitor of Metalloproteinase-2 (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinase 9, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2.
- blood supply : Leg, Lymphatic Vessels.
- chemistry : Lymph.
- metabolism : Lymph, Lymphatic Vessels.
- physiology : Signal Transduction.
- Healthy Volunteers, Humans, Male, Serum.
Abstract
Url:
DOI: 10.1089/lrb.2013.0014
PubMed: 24364843
PubMed Central: 3875199
Affiliations:
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Le document en format XML
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Olszewski</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Miller, Norman E" sort="Miller, Norman E" uniqKey="Miller N" first="Norman E." last="Miller">Norman E. Miller</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24364843</idno><idno type="pmc">3875199</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875199</idno><idno type="RBID">PMC:3875199</idno><idno type="doi">10.1089/lrb.2013.0014</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003036</idno><idno type="wicri:Area/Pmc/Curation">003035</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003035</idno><idno type="wicri:Area/Pmc/Checkpoint">001F74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001F74</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001762</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001762</idno><idno type="wicri:Area/PubMed/Curation">001762</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001762</idno><idno type="wicri:Area/PubMed/Checkpoint">001762</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001762</idno><idno type="wicri:Area/Ncbi/Merge">006089</idno><idno type="wicri:Area/Ncbi/Curation">006089</idno><idno type="wicri:Area/Ncbi/Checkpoint">006089</idno><idno type="wicri:doubleKey">1539-6851:2013:Zaleska M:signaling:proteins:are</idno><idno type="wicri:Area/Main/Merge">003162</idno><idno type="wicri:Area/Main/Curation">003157</idno><idno type="wicri:Area/Main/Exploration">003157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Signaling Proteins Are Represented in Tissue Fluid/Lymph from Soft Tissues of Normal Human Legs at Concentrations Different from Serum</title><author><name sortKey="Zaleska, Marzanna" sort="Zaleska, Marzanna" uniqKey="Zaleska M" first="Marzanna" last="Zaleska">Marzanna Zaleska</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Olszewski, Waldemar L" sort="Olszewski, Waldemar L" uniqKey="Olszewski W" first="Waldemar L." last="Olszewski">Waldemar L. Olszewski</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Miller, Norman E" sort="Miller, Norman E" uniqKey="Miller N" first="Norman E." last="Miller">Norman E. Miller</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author></analytic><series><title level="j">Lymphatic Research and Biology</title><idno type="ISSN">1539-6851</idno><idno type="eISSN">1557-8585</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytokines (metabolism)</term><term>Healthy Volunteers</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (metabolism)</term><term>Leg (blood supply)</term><term>Lymph (chemistry)</term><term>Lymph (metabolism)</term><term>Lymphatic Vessels (blood supply)</term><term>Lymphatic Vessels (metabolism)</term><term>Male</term><term>Matrix Metalloproteinase 9 (metabolism)</term><term>Serum</term><term>Signal Transduction (physiology)</term><term>Tissue Inhibitor of Metalloproteinase-1 (metabolism)</term><term>Tissue Inhibitor of Metalloproteinase-2 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cytokines (métabolisme)</term><term>Humains</term><term>Inhibiteur tissulaire de métalloprotéinase-1 (métabolisme)</term><term>Inhibiteur tissulaire de métalloprotéinase-2 (métabolisme)</term><term>Jambe ()</term><term>Lymphe ()</term><term>Lymphe (métabolisme)</term><term>Matrix metalloproteinase 9 (métabolisme)</term><term>Mâle</term><term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term><term>Sérum</term><term>Transduction du signal (physiologie)</term><term>Vaisseaux lymphatiques ()</term><term>Vaisseaux lymphatiques (métabolisme)</term><term>Volontaires sains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Intercellular Signaling Peptides and Proteins</term><term>Matrix Metalloproteinase 9</term><term>Tissue Inhibitor of Metalloproteinase-1</term><term>Tissue Inhibitor of Metalloproteinase-2</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Leg</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Inhibiteur tissulaire de métalloprotéinase-1</term><term>Inhibiteur tissulaire de métalloprotéinase-2</term><term>Lymphe</term><term>Matrix metalloproteinase 9</term><term>Protéines et peptides de signalisation intercellulaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Healthy Volunteers</term><term>Humans</term><term>Male</term><term>Serum</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Jambe</term><term>Lymphe</term><term>Mâle</term><term>Sérum</term><term>Vaisseaux lymphatiques</term><term>Volontaires sains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><bold><italic>Background:</italic></bold> The mobile intercellular fluid flowing to and in the lymphatics contains filtered plasma products and substances synthesized and excreted by tissue cells. Among them are signaling proteins such as cytokines, chemokines, enzymes, and growth factors. They act locally in autocrine and paracrine systems regulating cell metabolism, proliferation, and formation of the ground matrix. They play an immunoregulatory role in infections, wound healing, and tumor cell growth.</p><p><bold><italic>Methods and Results:</italic></bold> In this study we measured the concentration of selected cytokines, chemokines, tissue enzymes, and growth factors in tissue fluid/lymph drained from normal human leg soft tissues. Legs exposed to infections and trauma often result in development of lymphedema. Lymph was drained from superficial calf lymphatics using microsurgical techniques. Our studies showed generally higher concentrations of cytokines, chemokines, enzymes, and growth factors in lymph than in serum. The total protein L/S ratio was 0.22, whereas that of various lymph signaling proteins ranged between 1 and 10.</p><p><bold><italic>Conclusions:</italic></bold> This indicates that in addition to proteins filtered from blood, local cells contribute to lymph concentration by own production, depending on the actual cell requirement. Moreover, there were major individual differences of lymph levels with simultaneous stable serum levels. This suggests existence of a local autonomous regulatory humoral mechanism in tissues, not reflected in serum.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><name sortKey="Miller, Norman E" sort="Miller, Norman E" uniqKey="Miller N" first="Norman E." last="Miller">Norman E. Miller</name><name sortKey="Olszewski, Waldemar L" sort="Olszewski, Waldemar L" uniqKey="Olszewski W" first="Waldemar L." last="Olszewski">Waldemar L. Olszewski</name><name sortKey="Zaleska, Marzanna" sort="Zaleska, Marzanna" uniqKey="Zaleska M" first="Marzanna" last="Zaleska">Marzanna Zaleska</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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